化学化工学院“智汇讲坛”学术报告

报告题目：@催化-催化的新领域

报 告 人: 张绪穆 教授

时 间：2024年7月14日（星期日）上午10:00

地 点：理生楼A302-1

报告人简介: 俄罗斯工程院外籍院士，南方科技大学坪山生物医药研究院院长，南方科技大学化学系讲席教授、鹏程孔雀特聘教授，国家重大人才专家，国家重大人才化学化工专委会主任，杰出青年基金（B）获得者，

第一位获美国化学会Arthur C.Cope Scholar奖的中国内地科学家，深圳市海外高层次人才“孔雀计划”A 类，第六届中国化学会-赢创化学创新奖杰出科学家，深圳市自然科学一等奖获得者，中国科技产业化促进会科学技术奖科技创新二等奖获得者，凯特立斯科技有限公司董事长，深圳安泰维生物医药有限公司董事长，张绪穆教授发表学术论著433余篇，在 Science; Nature Chem., Nature Commum., J.Am.Chem.Soc., Angew.Chem. 等学术刊物上发表学术论著380余篇，论文他引>20000 多次,其中单篇论文他引>1800次，H-index>80。

Abstract:

Highly efficient and enantioselective hydrogenation is a key generic technology for green drug synthesis. In 2016, Zhang and coworkers creatively introduced ferrocene skeleton into the tridentate ligand and designed and synthesized a new f-amphox ligand, which showed ultra-high activity and enantioselectivity (>1,000,000 TON, 99% ee) in the hydrogenation of ketones. On this basis of amphox, Zhang and coworkers successively developed chiral tridentate ligands f-amphol, f-ampha and f-amphamide based on ferrocene skeleton, as well as electron-rich Heng-PNP based on rigid skeleton. In 2022, Xumu Zhang proposed the concept of ate catalysis (@ catalysis) and a tetradentate ligand based on the ferrocene skeleton, termed as f-phamidol, was developed based on this concept, which can obtain a TON of up to 13,425,000 in asymmetric hydrogenation of ketones. These multidentate ligands have been applied to the green synthesis of many important drugs such as Ezetimibe, Montelukast, Phenylephrine, Nicotine, etc.

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2024年7月9日